Can you breed siblings from different litters?

Can you breed siblings from different litters?

You can breed a sister and brother but is is not recommended because this is considered in-breeding and poses the risk of selecting for certain genes that can lead to increased chance of a lot of disease processes and abnormalities.

What happens if a dog gets pregnant by her brother?

After getting impregnated by her brother, there’s a high chance that female dogs will not deliver healthy babies. They may come out without any problems, but most cases of inbreeding result in spontaneous miscarriages and uterine complications. The hormones tend to go out of whack with incestuous pregnancies.